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. 2021 Jun 24;12:700366. doi: 10.3389/fphar.2021.700366

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Copyright © 2021 Lin, Guan, Meng, Uzui and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SGLT1 is downregulated in the experimental diabetic cardiac fibrosis model and high-glucose–induced CFs. (A) The mRNA level of SGLT1 was detected using RT‐qPCR (n = 6). (B) The protein level of SGLT1 was analyzed using western blot analysis (n = 6). (C) The protein levels of SGLT1, collagen I, and collagen III were evaluated using immunohistochemical staining. Relative expression of SGLT1 (D) and collagen I and collagen III (E) was found using semiquantitative analysis based on immunohistochemistry. (F) The morphology of CFs with or without high-glucose stimulation was imaged under an optical microscope. (G) The protein level of SGLT1 was analyzed by immunofluorescent staining in high-glucose–induced CFs. (H) The protein levels of SGLT1, collagen I, and collagen III were analyzed using western blot analysis in high-glucose–induced CFs (n = 3).