FIGURE 3.

Inactivation of FVIIa variants by AT and TFPI. (A) There is no significant difference among CT‐001, CT‐001(Sial), dWT FVIIa, and WT FVIIa in response to inhibition by the presence of 125 nM of AT and heparin. Data are displayed as an average of three independent experiments. (B) CT‐001, CT‐001(Sial), dWT FVIIa, and WT FVIIa exhibited similar sensitivity to TFPI inhibition. Data are displayed as an average of three independent experiments. AT, antithrombin; dWT, desialylated wild‐type; FVIIa, activated factor VII; TFPI, tissue factor pathway inhibitor