Figure 1.

RTX treatment impairs thermal nociception but causes delayed and sustained tactile allodynia. A–C, Time course of the effect of RTX treatment on nociceptive responses to a heat stimulus (A), a pressure stimulus (B), and von Frey filaments (C) in rats. Data are expressed as means ± SEM (n = 9 rats per group). **p < 0.01, ***p < 0.001 compared with the baseline (BL) before RTX injection, ^#p < 0.05, ^###p < 0.001 compared with the vehicle group at the same time point. Two-way ANOVA followed by Tukey's post hoc test.