Table 8.

Effects of 5-HT receptor activation on Shox2 in properties^a

		Uninjured			SCI			Uninjured vs SCI
		mean ± SD	test	p	mean ± SD	test	p	test	p
5-HT7 receptor activation	Em, Δ from antagonist	3.6 ± 3	t(7) = 3.2	0.01*	3.5 ± 4	t(11) = 2.9	0.01*	t(18) = 0.02	0.9
	Rheobase current (% of antagonist)	87.0 ± 25	t(7) = 1.4	0.1	77.8 ± 20	t(12) = 3.9	0.001*	t(19) = 0.9	0.3
	Firing frequency at 1.5× rheobase (% of antagonist)	119.2 ± 44	W = 9	0.4	101.1 ± 39	W = −5	0.9	U = 24	0.3
5-HT2A receptor activation	Em, Δ from antagonist	0.6 ± 3	W = −2	0.9	0.4 ± 2	t(9) = 0.5	0.6	U = 33	0.5
	Rheobase current (% of antagonist)	98.4 ± 29	t(7) = 0.1	0.8	91.4 ± 26	W = −14	0.2	U = 33.5	0.5
	Firing frequency at 1.5× rheobase (% of antagonist)	125.6 ± 57	W = −14	0.4	91.0 ± 24	t(9) = 1.1	0.2	U = 16.5	0.3
5-HT2B/2C receptor activation	Em, Δ from antagonist	−0.1 ± 1	t(6) = 0.2	0.8	3.1 ± 3	t(8) = 2.6	0.02*	t(14) = 2.3	0.03*
	Rheobase current (% of antagonist)	92.1 ± 19	t(6) = 1.0	0.3	73.2 ± 17	t(8) = 4.1	0.003*	t(14) = 1.7	0.1
	Firing frequency at 1.5× rheobase (% of antagonist)	99.3 ± 9	W = −1	0.9	106.9 ± 22	t(7) = 0.8	0.4	U = 20	0.6

^aUninjured and SCI, one-sample t test or Wilcoxon signed rank test (W); Uninjured versus SCI, unpaired t test or Mann–Whitney U test.

*Statistical significance: p < 0.05.