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. 2021 Jul 8;16(7):e0252132. doi: 10.1371/journal.pone.0252132

Table 4. Relationship between MSI2 and E-cadherin in CRC.

Clinicopathological parameters Total Number of patients MSI2 protein expression χ2 p-value r
Low (n. %) High (n. %)
Expression level in primary tumor
E-cadherin in primary tumor
Low 12 3 (25%) 9 (75%) 0.000 1.000 -0.040
High 16 5 (32%) 11 (68%)
E-cadherin in metastasis
Low 12 5 (42%) 7 (58%) 1.750 0.186 0.333
High 16 2 (12%) 14 (88%)
Expression level in metastasis
E-cadherin in primary tumor
Low 12 1 (8%) 11 (92%) 0.650 0.420 -0.256
High 16 5 (32%) 11 (68%)
E-cadherin in metastasis
Low 12 6 (50%) 6 (50%) 4.861 0.027 0.500
High 16 1 (6%) 15 (94%)

Categorical data were evaluated using the Pearson χ2 test, adjusted by Yates’s correction for continuity. The correlation coefficients between protein expression and clinical and pathological parameters were estimated using Spearman correlation.