Table 1.

Chemokines Expression and T Cell Subsets.

Chemokine Receptor	Chemokine Ligand	T Cell Subset	Ligand Expression Pattern	Axis Function
CCR7	CCL19 CCL21	Naïve Central memory	Secondary lymphoid organs Blood-brain barrier	Homing of T cells to various secondary lymphoid organs, trafficking within spleen; recruitment to the CNS
CXCR3	CXCL4 CXCL9 (MIG) CXCL10 (IP-10) CXCL11 (I-TAC)	Th1 CD8+ cytotoxic	Sites of injury and inflammation	Recruitment to inflammatory sites and wound healing
CCR5	CCL3, CCL3L1 CCL4 (MIP-1) CCL5 (RANTES)	Th1	Sites of injury and inflammation	Recruitment to inflammatory sites and wound healing
CCR4	CCL2 (MCP-1) CCL4 (MIP-1) CCL5 (RANTES) CCL17 (TARC, CCL22 (Macrophage-derived chemokine)	Th2 Th17 Th22 Treg	Sites of injury and inflammation	Recruitment to inflammatory sites; plays a role in pathogenesis of inflammatory diseases
CCR3	CCL5 (RANTES) CCL7 (MCP-3) CCL11 CCL13 (MCP-4) CCL26 (eotax-in3)	Th2	Sites of inflammation or infection	Recruitment to inflammatory or infection sites
CCR6	CCL20 (MIP-3α)	Th17 Th22	Mucosal lymphoid tissue Lymph nodes Liver Appendix	Recruitment in response to infection or inflammation at these sites
CCR10	CCL27 CCL28	Th22 Treg	Skin	T cell-mediated skin inflammation
CXCR5	CXCL13 (BLC/BCA-1)	Tfh	B cell follicles of lymph nodes Spleen	Enables T cells to migrate to lymph node B cell zones
CCR8	CCL1 CCL8	Th2	Thymus	Positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues
CCR1	CCL3 (MIP-1 α) CCL5 (RANTES) CCL7 (MCP-3) CCL23 (MPIF-1)	Th1	Sites of inflammation or infection	Recruitment to inflammatory or infection sites