Figure 2.

Type I (left) and Type II (right) binding modes of tetralones in the active site of MIF, identified through reversible docking experiments. Carbons of (24) are coloured orange (Type I) and yellow (Type II). Residues are coloured according to their type of interaction with the ligand: yellow residues form H-bonds, blue residues form π–π stacking and green form cation-π interactions, red residues are hydrophobic, and the catalytic Pro1 is coloured cyan. The grey area is the inner surface of the binding site. Red dashed lines indicate steric clashes.