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. 2021 Jul 6;36(1):1357–1369. doi: 10.1080/14756366.2021.1916010

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — The effect of compound 24 on thermoregulation and locomotor activity in mice. The effects of compound 24 (or vehicle) pre-treatment at −30 min on the abdominal temperature (top) and locomotor activity (bottom) of mice treated with lipopolysaccharide (LPS) or saline at time zero (doses indicated). Pre-treatment with compound 24 significantly exaggerates the hypothermic response to LPS, while it does not further reduce the already near-zero level of locomotor activity in LPS-treated mice. The number of mice was 8 (n = 8) in each group. Data are presented as means ± SD.