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. 2021 Jun 22;13(12):16367–16380. doi: 10.18632/aging.203162

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Copyright: © 2021 Liao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Tumor-infiltrating immune cells associated with S100A9 expression in HCC. (A) Differential infiltration of immune cells based on S100A9 expression in groups from the TCGA-LIHC cohort. The proportions of 22 immune infiltrates in tumor (n = 49) and nontumor tissue (n = 7) were estimated using the CIBERSORT algorithm. (B–E) Prognostic value of M0, M1, M2 and total (M0 + M1 + M2) macrophage densities in HCC (n = 49). (F) The densities of S100A9⁺ cells and CD15⁺ neutrophils and CD68⁺ macrophages were analyzed using Pearson correlation analysis (n = 382). ^***P < 0.001.