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Schematic signal pathways of D-galactose-induced cardiac senescence and acacetin protection against the cardiac senescence. D-galactose increases AGEs production and ROS accumulation and decreases mitophagy thereby promoting cardiac senescence. Acacetin, in addition to decreasing AGEs, increases NAD+/NADH ratio through NAMPT followed by activation of Sirt1/Sirt6/AMPK thereby preserving mitochondrial function via increasing mitophagy.
