Table 3. Mean changes in the main secondary outcome measures from baseline to the study endpoint.
| Baseline scores | Changes from baseline to study end | P* | ||||||||
| FMI (n = 48) | HMI (n = 50) | Control (n = 42) | FMI (n = 48) | HMI (n = 50) | Control (n = 42) | FMI vs. Control | HMI vs. Control | |||
| Mini-Mental State Examination† | 28.1 (1.8) | 28.0 (1.8) | 27.2 (2.5) | 0.04 (1.92) | 0.18 (1.79) | -0.24 (2.94) | 0.37 | 0.28 | ||
| CDR-SB | 0.46 (0.56) | 0.49 (0.60) | 0.38 (0.43) | 0.03 (0.53) | -0.09 (0.46) | 0.50 (2.50) | 0.20 | 0.10 | ||
| Prospective Memory Test† | 9.1 (2.6) | 8.8 (2.7) | 9.3 (2.6) | 0.24 (2.56) | 0.48 (2.98) | 0.15 (2.71) | 0.99 | 0.89 | ||
| PRMQ | 34.3 (10.6) | 34.0 (11.2) | 32.0 (11.6) | -2.46 (9.87) | -3.72 (9.98) | 0.90 (6.79) | 0.11 | 0.01 | ||
| PRMQ by caregiver | 31.1 (10.5) | 29.1 (9.3) | 26.4 (10.3) | -3.58 (8.49) | -2.12 (8.16) | 2.17 (13.74) | 0.16 | 0.19 | ||
| Cognitive Complaint Interview | 4.4 (2.0) | 4.2 (2.1) | 3.8 (2.4) | -1.31 (2.20) | -1.12 (1.75) | -0.61 (1.91) | 0.28 | 0.24 | ||
| Geriatric Depression Scale-15 items | 4.5 (3.8) | 4.2 (4.2) | 4.2 (3.4) | -1.35 (3.45) | -1.24 (3.09) | 0.12 (2.60) | 0.03 | 0.01 | ||
| Bayer Activities of Daily Living | 1.76 (1.11) | 1.51 (0.63) | 1.64 (1.02) | -0.30 (0.90) | -0.13 (0.66) | 0.11 (1.12) | 0.06 | 0.14 | ||
| Quality of Life in Alzheimer’s disease† | 33.8 (5.6) | 33.2 (5.3) | 32.5 (6.1) | 2.03 (5.27) | 3.01 (4.03) | 0.74 (4.49) | 0.04 | 0.001 | ||
| Pittsburgh Sleep Quality Index | 6.5 (3.7) | 7.2 (3.6) | 7.4 (4.1) | 0.06 (3.69) | -0.76 (3.54) | 0.51 (3.30) | 0.24 | 0.04 | ||
| SPPB† | 11.4 (1.2) | 11.3 (1.2) | 11.1 (1.3) | 0.33 (1.17) | 0.52 (1.20) | 0.33 (1.37) | 0.24 | 0.03 | ||
| Timed Up and Go test, sec | 6.5 (1.6) | 6.5 (1.5) | 6.6 (1.8) | -0.18 (1.84) | -0.17 (1.47) | 0.54 (2.46) | 0.02 | 0.01 | ||
| Mini Nutritional Assessment† | 12.0 (2.1) | 11.9 (2.1) | 12.1 (2.3) | 0.56 (2.24) | 0.78 (2.48) | -0.02 (2.40) | 0.27 | 0.14 | ||
| Nutrition Quotient for elderly† | 64.5 (10.5) | 64.9 (9.7) | 64.9 (9.4) | 5.67 (8.93) | 6.00 (7.77) | 1.41 (8.12) | 0.01 | 0.003 | ||
| Systolic blood pressure, mmHg | 127.8 (16.1) | 126.7 (13.0) | 132.1 (16.6) | -1.54 (18.49) | 0.02 (14.96) | 0.44 (17.12) | 0.03 | 0.08 | ||
| Diastolic blood pressure, mmHg | 73.8 (10.4) | 74.3 (10.2) | 74.8 (8.3) | -1.54 (12.53) | -4.06 (10.26) | 0.68 (8.77) | 0.13 | 0.006 | ||
| Body fat mass, kg | 18.6 (4.9) | 19.4 (5.6) | 20.9 (4.8) | -0.19 (1.67) | -0.22 (2.11) | 0.68 (2.41) | 0.009 | 0.02 | ||
| Self Determination Index† | 20.7 (16.1) | 17.6 (21.5) | 15.0 (23.1) | 10.13 (17.12) | 14.68 (21.71) | 0.63 (14.95) | 0.001 | <0.001 | ||
Values are shown as the mean (SD). FMI, facility-based multidomain intervention; HMI, home-based multidomain intervention; CDR-SB, Clinical Dementia Rating-Sum of Boxes; PRMQ, Prospective Retrospective Memory Questionnaire; SPPB, Short Physical Performance Battery. *Analysis of covariance with each baseline score as a covariate †Higher scores indicate better performance.