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. 2021 Jun 16;13(12):16287–16315. doi: 10.18632/aging.203157

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Copyright: © 2021 Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The 2D and 3D structures of five top-scoring small-molecule drugs. (A) Top five compounds acting on the RNA-binding domain of METTL14. (B–F) 2D and 3D mapping of the binding interaction between the top five compounds (Z1791109186, Z1445387105, Z89321655, HY-N0055, and HY-102053) and METTL14. (G) The five preferred compounds targeting the m6A-binding domain of the YTHDC1 protein. (H–L) 2D and 3D mapping of the binding between the top five compounds (Z1246434517, Z2283664368, Z1455079275, HY-N0343, and HY-B0069) and YTHDC1.