Table 3. Univariate COX regression analysis of m6A regulatory genes for endometrial cancer patients' overall survival (OS) and disease-free survival (DFS).
OS | DFS | |||||||
Variable | HR | P | Lower 95%CI | Upper 95%CI | HR | P | Lower 95% CI | Upper 95%CI |
Age | 1.035 | 0.001 | 1.015 | 1.056 | 1.009 | 0.477 | 0.984 | 1.034 |
Stage | 4.085 | 0.001 | 2.673 | 6.243 | 2.682 | 0.001 | 1.552 | 4.634 |
Grade | 3.778 | 0.001 | 2.133 | 6.693 | 1.468 | 0.180 | 0.837 | 2.574 |
Invasion | 1.012 | 0.001 | 1.008 | 1.016 | 1.009 | 0.079 | 0.999 | 1.018 |
Lymph Metastasis | 0.973 | 0.011 | 0.952 | 0.994 | 1.006 | 0.589 | 0.983 | 1.030 |
PIK3CA | 0.680 | 0.092 | 0.434 | 1.066 | 0.637 | 0.132 | 0.354 | 1.146 |
KRAS | 0.571 | 0.111 | 0.286 | 1.138 | 0.640 | 0.304 | 0.274 | 1.498 |
POLE | 0.640 | 0.184 | 0.331 | 1.237 | 0.511 | 0.153 | 0.203 | 1.283 |
TP53 | 1.326 | 0.198 | 0.863 | 2.037 | 1.407 | 0.229 | 0.807 | 2.453 |
PIK3R1 | 1.322 | 0.233 | 0.836 | 2.090 | 1.034 | 0.915 | 0.553 | 1.934 |
FBXW7 | 1.210 | 0.490 | 0.704 | 2.080 | 1.180 | 0.651 | 0.576 | 2.417 |
PTEN | 0.867 | 0.507 | 0.568 | 1.323 | 0.880 | 0.642 | 0.513 | 1.509 |
PPP2R1A | 0.981 | 0.950 | 0.544 | 1.771 | 0.351 | 0.078 | 0.109 | 1.125 |
W-E- | 2.337 | 0.0001 | 1.533 | 3.564 | 1.831 | 0.037 | 1.036 | 3.236 |
Note: R-W-: m6A regulator alteration (Writer loss + Eraser loss); HR: (95% CI).