Table 2. Correlation of IL-6, STAT3, p-STAT3, JAK2, p-JAK2 and CyclinD1 expressions with clinicopathological features of NPC patients.

Clinicopathological features	Case	STAT3			p-STAT3			JAK2			p-JAK2			IL-6			CyclinD1
		Positive	Negative	p	Positive	Negative	p	Positive	Negative	p	Positive	Negative	p	Positive	Negative	p	Positive	Negative	p
Age				0.227			0.599			0.614			0.453			0.253
< 45 years	52	39	13		36	16		32	20		37	15		43	9		35	17	0.518
≥ 45 years	65	42	23		42	23		37	28		42	23		48	17		40	25
Gender				0.059			0.189			0.394			0.269			0.321
Male	64	49	15		46	18		40	24		46	18		52	12		44	20	0,249
Female	53	32	21		32	21		29	24		33	20		39	14		31	22
Type				0.187			0.259			0.139			0.216			0.630
Squamous carcinoma	9	8	1		7	2		8	1		8	1		8	1		8	1	0.165
Poorly differentiated carcinoma	93	60	33		58	35		51	42		59	34		70	23		55	38
Undifferentiated carcinoma	9	8	1		8	1		7	2		8	1		8	1		7	2
Adenosquamous carcinoma	6	5	1		5	1		3	3		4	2		5	1		5	1
LNM				0.032			0.048			0.001			0.001			0.003
Yes	66	51	15		49	17		48	18		52	14		58	8		49	17	0.009
No	51	30	21		29	22		21	30		27	24		33	18		26	15
TNM stage				0.010			0.003			0.003			0.023			< 0.001
I + II	36	19	17		17	19		14	22		19	17		20	16		17	19	0.011
III + IV	81	62	19		61	20		55	26		60	21		71	10		58	23

Abbreviations: IL-6: interleukin-6; STAT3: Signal transducers and activators of transcription 3; JAK2: Janus kinase 2; NPC: nasopharyngeal carcinoma; LNM: lymph node metastasis; TNM: tumor node metastasis.