Table 2. Correlation analysis between NR1D1/PER1 and gene biomarkers of immune cells in STAD.
| Description | Gene markers | STAD | |||
| NR1D1 | PER1 | ||||
| Cor | P-value | Cor | P-value | ||
| CD8+ T cell | CD8A CD8B |
–0.139 –0.063 |
** 0.203 |
0.331 0.255 |
*** *** |
| T cell (general) | CD3D CD3E CD2 |
–0.213 –0.13 –0.177 |
*** ** *** |
0.256 0.31 0.277 |
*** *** *** |
| B cell | CD19 CD79A |
–0.113 –0.158 |
* ** |
0.366 0.366 |
*** *** |
| Monocyte | CD86 CD115(CSF1R) |
–0.133 –0.077 |
** 0.119 |
0.305 0.414 |
*** *** |
| TAM | CCL2 CD68 IL10 |
–0.076 0.079 –0.102 |
0.121 0.107 * |
0.249 0.198 0.29 |
*** *** *** |
| M1 Macrophage | INOS (NOS2) IRF5 COX2(PTGS2) |
–0.016 0.101 0.016 |
0.74 * 0.745 |
–0.057 0.224 0.173 |
0.245 *** *** |
| M2 Macrophage | CD163 VSIG4 MS4A4A |
–0.043 –0.081 –0.13 |
0.379 0.0994 ** |
0.405 0.335 0.393 |
*** *** *** |
| Neutrophils | CD66b (CEACAM8) CD11b (ITGAM) CCR7 |
0.048 –0.022 –0.104 |
0.325 0.659 * |
0.006 0.407 0.449 |
0.905 *** *** |
| Natural killer cell | KIR2DL1 KIR2DL3 KIR2DL4 KIR3DL1 KIR3DL2 KIR3DL3 KIR2DS4 |
–0.176 –0.129 –0.158 –0.189 –0.168 0.035 –0.167 |
*** ** ** *** *** 0.478 *** |
0.142 0.072 0.079 0.171 0.198 0.058 0.112 |
** 0.143 0.106 *** *** 0.24 * |
| Dendritic cell | HLA-DPB1 HLA-DQB1 HLA-DRA HLA-DPA1 BDCA-1(CD1C) BDCA-4(NRP1) CD11c (ITGAX) |
–0.119 –0.065 –0.112 –0.066 –0.163 0.01 –0.053 |
* 0.185 * 0.179 *** 0.839 0.282 |
0.321 0.238 0.243 0.29 0.382 0.457 0.344 |
*** *** *** *** *** *** *** |
| Th1 | T-bet (TBX21) STAT4 STAT1 IFN-g (IFNG) TNF-a (TNF) |
–0.12 –0.167 0.063 –0.081 –0.002 |
* *** 0.203 0.0975 0.974 |
0 .307 0.418 0.15 0 0.126 |
*** *** ** 0.996 * |
| Th2 | GATA3 STAT6 STAT5A IL13 |
–0.082 0.18 –0.008 0.017 |
0.0934 *** 0.877 0.723 |
0.344 0.227 0.376 0.059 |
*** *** *** 0.232 |
| Tfh | BCL6 IL21 |
0.081 –0.163 |
0.0996 *** |
0.571 0.096 |
*** * |
| Th17 | STAT3 IL17A |
0.102 0.068 |
* 0.167 |
0.445 –0.164 |
*** *** |
| Treg | FOXP3 CCR8 STAT5B TGFb (TGFB1) |
–0.037 –0.034 0.065 0.039 |
0.448 0.487 0.185 0.423 |
0.305 0.354 0.45 0.455 |
*** *** *** *** |
| T cell exhaustion | PD-1 (PDCD1) CTLA4 LAG3 TIM-3 (HAVCR2) GZMB |
–0.085 –0.066 –0.114 –0.102 –0.111 |
0.0831 0.179 * * * |
0.278 0.238 0.229 0.309 0.098 |
*** *** *** *** * |
*p < 0.05, **p < 0.01, ***p < 0.001.