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. 2021 Jun 18;13(12):16445–16470. doi: 10.18632/aging.203166

Table 2. The general information distinguished by ITGAM expression and the characteristics of AML patients.

General information ITGAM
Positive (N = 46) Negative (N = 133)
Age 46.78 ± 16.99 46.62 ± 15.43
Gender Female (19, 41.30%) Male (27, 58.70%) Female (72, 54.14%) Male (61, 45.86%)
Race Han (31, 67.39%) Uyghur (15, 32.61%) Han (102, 76.69%) Uyghur (31, 23.31%)
WBC** 62.99 ± 71.05 34.81 ± 59.55
Hb 81.28 ± 22.88 80.99 ± 22.80
PLT 58.59 ± 57.76 79.71 ± 153.08
Diagnosis
M1 4 (8.70%) 7 (5.26%)
M2*** 18 (39.13%) 100 (75.19%)
M4 8 (17.39%)- 10 (7.52%)
M5** 16 (34.78%) 15 (11.28%)
M6 1 (0.75%)
Prognostic generate
WT-1 33 (71.74%) 94 (70.68%)
ASXL1 13 (28.26%) 25 (18.80%)
TET-2 11 (23.91%) 22 (16.54%)
DNMT3A 6 (13.04%) 13 (9.77%)
CEBPA 4 (8.70%) 12 (9.02%)
TP53 6 (13.04%) 5 (3.76%)
NPM1 4 (8.70%) 15 (11.28%)
FLT3 4 (8.70%) 13 (9.77%)
IDH1/IDH2 0/3 (6.52%) 3 (2.26%)/2 (1.50%)
C-kit 3 (6.52%) 10 (7.52%)
RUNX1 2 (4.35%) 3 (2.26%)
NRAS 2 (4.35%) 3 (2.26%)
Regimens
Un-Treatment 8 (17.39%) 11 (8.15%)
IA 23 (50.00%) 73 (54.89%)
DA 9 (19.57%) 38 (28.57%)
CAG 4 (8.70%) 3 (2.22%)
HMAs 2 (4.35%) 8 (5.93%)
Treatment outcomes (N = 38) (N = 122)
CR* 20 (52.63%) 90 (73.77%)
PR 4 (10.53%) 5 (4.10%)
NR 8 (21.05%) 21 (17.21%)
Death 6 (15.79%) 6 (4.92%)

***P < 0.001; **P < 0.01; *P < 0.05. Abbreviations: CR: complete remission; PR: partial remission; NR: no response; WBC: white blood cells; Hb: hemoglobin; PLT: platelet; IA: idarubicin, cytarabine; DA: daunorubicin, cytarabine; CAG: cytarabine, aclacinomycin, and granulocyte colony-stimulating factor; HMAs: hypomethylating agents mainly contain azacytidine or decitabine.