Table 1.
Simplified summary of the triage protocol to be followed in the management of Urological cancers during COVID-19
Site of Cancer | Cancer stage | Management |
---|---|---|
Kidney | cT1a | Postpone Sx for 6 months |
≥cT1b | Postpone Sx for 3 months | |
Any T, Hematuria/ symptomatic/Renal vein/IVC involvement |
Immediate Sx | |
Metastatic RCC IMDC Good and Intermediate risk | TTX, CN after 3-6 month | |
Metastatic RCC IMDC poor risk | TTX | |
NMIBC | Low risk | Postpone Sx for 3 months |
Intermediate risk | Prefer Sx | |
High risk | Sx | |
Any tumor with hematuria | Sx | |
MIBC | cT2N0 | Trimodal therapy/Sx |
≥cT/ any N+ | Sx within 3 months | |
pT3/T4, p N1-N3 | Defer adjuvant CT after Sx, Immuno preferred | |
Metastatic bladder cancer | Defer CT, Immuno preferred | |
Metastatic bladder cancer with hematuria | Hemostatic RT/Endoscopic fulguration | |
Prostate | Low risk | AS/Defer treatment for 6 months |
Intermediate risk | Defer treatment for 3-6 months | |
High risk | Neoadjuvant ADT for 3-6 months followed by Sx/RT | |
Metastatic | LHRH agonist preferred | |
CRPC | Abiraterone/Enzalutamide preferred. Avoid Docetaxel CT. | |
Penis | cTis, cTa, cT1 | Postpone Sx for 3 months |
cT2/cT3 | Sx | |
cT4 | Sx + adjuvant CT | |
B/l negative groin | ||
Low risk | Surveillance | |
Intermediate risk | Surveillance | |
High risk | Sx postponed for 3 months | |
Positive mobile nodes | Sx | |
Positive fixed nodes/>4cm | Neoadjuvant CT followed by Sx | |
Metastatic disease | Palliative CT | |
Testis | Seminoma | |
CS I Low risk | Surveillance | |
CS I High risk | Surveillance/CT | |
CS II A, IIB | CT/RT | |
CS IIC, III | CT | |
Non Seminoma | ||
CS I A | Surveillance | |
CS IB | Surveillance | |
CS IS | CT | |
CS IIA, IIB | CT | |
CS II C, III | ||
Good risk | CT | |
Intermediate risk | CT | |
High risk | CT |
Sx: Surgery, TTx: Targeted therapy, CN: Cytoreductive nephrectomy, NMIBC: Non muscle invasive bladder cancer, MIBC: Muscle invasive balader cancer, CT: Chemotherapy, RT: Radiotherapy, AS: Active surveillance,