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. 2021 Jul 1;2021:9995342. doi: 10.1155/2021/9995342

Figure 4.

Figure 4

Wog prevented TAC-induced cardiac hypertrophy and dysfunction in vivo. (a, b) Echocardiographic data showed the effects of Wog on cardiac hypertrophy induced by TAC. EF: ejection fraction; FS: fractional shortening (n = 5); (c) representative M-mode echocardiograms from sham and TAC mice with vehicle or Wog; (d–f) histological staining of H&E and WGA of heart sections showed the inhibitory effect of Wog on cardiac hypertrophy after TAC surgery (magnification: ×200, scale bar: 20 μm). Quantitative analysis of cardiomyocyte cross-sectional area (n = 5); (g) representative hearts of mice that underwent sham or TAC surgery, followed by single intragastric administration of Wog (10 mg/kg/day) for 8 weeks; (h) quantitative analysis of the heart weight/body weight (HW/BW) ratio (n = 5); (i–k) mRNA expressions for Anp, Bnp, and Myhc-β determined by qRT-PCR (n = 5). ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 compared to sham; #P < 0.05, ##P < 0.01, and ###P < 0.001 compared to TAC.