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. 2021 Jun 14;49(12):7011–7034. doi: 10.1093/nar/gkab461

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — (A) Representative light microscopy images of HEK293T CTRL, ADAT2 KD and ADAT3 KD cells in the presence of the indicated stress agents. Those that directly affect the translation machinery are highlighted in purple. HygroB: hygromycin B. BlaS: blasticidin S. CHX: cycloheximide. (B) Cellular viability (metabolic activity) measured by WST-1 assays for the indicated cell lines in the presence of antibiotics depicted in (A). Shown are biological triplicates, their means and SD relative to untreated cells. n.s.: not statistically significant. *: P-value < 0.05. **: P-value < 0.01 (t-test). (C) Evaluation of cell adhesion to components of the extracellular matrix. Col I, II and IV: collagen I, II and IV respectively. FN: fibronectin. LN: laminin. TN: tenascin. VN: vitronectin. Box plots represent min-to-max cell adhesion relative to the means of HEK293T CTRL cells based on four biological replicates. n.s.: not statistically significant. *: P-value < 0.05. **: P-value < 0.01. ***: P-value < 0.001 (t-test). See also Supplementary Figure S3E.