Figure 11.

Examples of approaches for G4-targeting exploiting either loops or flanking regions. (A) Targeting of the BCL-2 long loop in cells, exploiting vehiculation through an adenoviral vector, as shown by Amato et al. (160). (B) Approach shown by Chen et al., for G4 detection using a turn-on fluorescent dye approach (162). (C) G4-templated synthesis of cyanine fluorophores, described by Ladame and co-workers (164). (D) c-Myc targeting using a clamp-based approach as proposed by Hao et al. (166). (E) Targeting of mutually-exclusive G4 sequences in the HIV-LTR genome, as proposed by Richter and colleagues (168).