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Overview of the PNA modifications described in this section employed to target G4 by inducing the formation of a PNA–DNA intermolecular quadruplex (A): i. Tcyp–PNA described by Englund et al. (118); ii. PNA modifications presented in the work by Armitage and colleagues (119). (B) The approach proposed by Komiyama and colleagues, describing the G4-formation-driven sequence-specific DNA scission; K corresponds to a lysine residue (122).
