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Examples illustrating the targeting of G3-sequences. (A) Schematic illustration of the methodology proposed by Ladame and colleagues, employing a 3G-PNA decorated with an acridone moiety (126). (B) Schematic illustration of the methodology proposed by Wen et al., employing a 3G-PNA conjugated with the G4-binding peptide RHAU23 (131). (C) Restoration of a stable G4 structure from an oxidized 8-oxoG-containing structure (134).
