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Examples of 4n-1 targeting strategies. (A) Sequence-specific targeting of 4n–1 sequence using a probe complementary to G4 flanking regions, as shown by Phan et al. (141). (B) Targeting of a guanine-deficient quadruplex, employing the G4-binding RHAU23 peptide linked to a guanine moiety (GRPC) (143).
