Table 1.
Basic Characteristics of 49 Cryptococcosis Patients With Cirrhosis
| Variables | Total (N = 49) |
|---|---|
| Age, y, median (range) | 54 (29–75) |
| Gender, male | 27 (55.1) |
| Etiology of cirrhosisa | |
| Viral hepatitis B infection | 28 (57.1) |
| Autoimmune liver disease | 13 (26.5) |
| Schistosomiasis | 3 (6.1) |
| Alcohol | 2 (4.1) |
| Wilson disease | 1 (2.0) |
| Drug-induced liver injury | 1 (2.0) |
| Cryptogenic cirrhosis | 3 (6.1) |
| Child-Pugh classification | |
| A | 17 (34.9) |
| B | 18 (36.7) |
| C | 14 (28.6) |
| Concurrent predisposing factors | 21 (65.3) |
| Glucocorticoid or immunosuppressant therapy | 12 (24.5) |
| Autoimmune disease | 11 (22.4) |
| Diabetes mellitus | 10 (20.4) |
| Splenectomy | 9 (18.4) |
| Solid organ tumor | 5 (10.2) |
| Hematological malignancy | 3 (6.1) |
| Past history of chemotherapy or radiotherapy | 3 (6.1) |
| Multisite cryptococcal infectionsb | 19 (38.8) |
| Groups by sites of infection | |
| Pulmonary cryptococcosis alone | 9 (18.3) |
| Cryptococcal meningitis | 38 (77.6) |
| Other extrapulmonary cryptococcosis | 2 (4.1) |
Data are presented as No. of patients (%) unless otherwise indicated.
Abbreviations: CM, cryptococcal meningitis; PC, pulmonary cryptococcosis.
aTwo patients with CM had 2 etiologies of cirrhosis at the same time.
bInfectious sites involved central nervous system (n = 38), lung (n = 21), bloodstream (n = 11), skin (n = 1), and bone (n = 1).