Table 3.
Safety Profiles of Initial Treatments
| ADR Category | AmB ± FC (n = 8) | AmB + FCZ ± FC (n = 5) | FCZ ± FC (n = 20) | P Value (AmB ± FC vs FCZ ± FC) | P Value (AmB + FCZ ± FC vs FCZ ± FC) |
|---|---|---|---|---|---|
| Patients with any ADR | 6 (75.0) | 3 (60.0) | 1 (5.0) | <.001 | .016 |
| Elevated serum creatinine | 3 (37.5) | 2 (40.0) | 1 (5.0) | .058 | .091 |
| Elevated ALP | 1 (12.5) | 0 (0.0) | 0 (0.0) | .286 | |
| Elevated GGT | 0 (0.0) | 1 (20.0) | 0 (0.0) | .200 | |
| Hypokalemia | 2 (25.0) | 1 (20.0) | 0 (0.0) | .074 | .200 |
| Altered mental status | 1 (12.5) | 0 (0.0) | 0 (0.0) | .286 | |
| Rash | 0 (0.0) | 1 (20.0) | 0 (0.0) | .200 | |
| Drug fever | 0 (0.0) | 1 (20.0) | 0 (0.0) | .200 |
Values are number of patients (percentage).
Abbreviations: ±, with or without; ADR, adverse drug reaction; ALP, alkaline phosphatase; AmB, amphotericin B; FC, flucytosine; FCZ, fluconazole; GGT, gamma-glutamyl transferase.