Table 4.

Profiles of 10 Patients With Cryptococcal Meningitis or Pulmonary Cryptococcosis Who Died During 1-Year Follow-up

No.	Age	Gender	Etiology of Cirrhosis	Child-Pugh Classification	Concurrent Predisposing Factors	Site of Infection	Antifungal Treatment	Time of Follow-up, d	Cause of Death
1	64	F	HBV	C	None	CNS	ICZ × 3 d	3	CM
2	74	F	PBC	C	RA, glucocorticoid therapy, diabetes mellitus	CNS	FCZ	4	Multiple organ dysfunction syndrome, CM
3	74	F	AIH	C	Splenectomy, glucocorticoid therapy	CNS, lung	FCZ	6	Multiple sites of cryptococcal infection
4	66	F	PBC	C	Sjogren syndrome	CNS	AmB + ICZ + FC × 3 d FCZ + FC × 5 d FCZ × 5 d	13	DIC secondary to cryptococcosis
5	60	M	HBV	B	None	CNS, bloodstream	ICZ × 17 d Liposomal AmB + ICZ × 3d	20	Cerebral herniation
6	47	F	HBV	C	Connective tissue disease	CNS, bloodstream	VCZ × 19 d FCZ × 9 d	28	DIC secondary to bacterial infection
7	65	F	AIH + PBC	C	AIHA, glucocorticoid therapy	Lung	FCZ × 31 d ICZ × 4 d	35	Secondary Aspergillus infection, hepatic, and respiratory failure
8	67	M	HBV	B	Splenectomy, hepatic tumor	CNS	AmB + FCZ × 14 d FCZ × 31 d	45	Decompensated cirrhosis, hepatic cancer
9	70	M	HBV	C	Diabetes mellitus	CNS	AmB × 38 d FCZ × 100 d	138	Cerebral herniation, AKI
10	58	M	HBV	A	None	CNS	Liposomal AmB × 25 d Liposomal AmB + VCZ × 30 d AmB × 9 d AmB + FCZ × 72 d FCZ × 81 d	217	Bacterial pneumonia

Abbreviations: AIH, autoimmune hepatitis; AIHA, autoimmune hemolytic anemia; AKI, acute kidney injury; AmB, amphotericin B; CM, cryptococcal meningitis; CNS, central nervous system; DIC, diffuse intravascular coagulation; F, female; FC, flucytosine; FCZ, fluconazole; HBV, hepatitis B virus; ICZ, itraconazole; M, male; PBC, primary biliary cholangitis; PC, pulmonary cryptococcosis; RA, rheumatic arthritis; VCZ, voriconazole.