Table 2.

Multivariate cox regression analysis for (a) OS and PFS and (b) RR and NRM.

			HR		[95%-CI]		p value
(A) OS and PFS
Remission at allo-SCT	No remission vs. CR MRD nega	OS	3.92		2.54–6.07		<0.0001
		PFS	3.73		2.44–5.70		<0.0001
	CR MRD pos vs. CR MRD nega	OS	1.18		0.70–2.00		0.531
		PFS	1.18		0.71–1.96		0.527
Conditioning	TBI vs. no TBI	OS	0.47		0.29–0.75		0.002
		PFS	0.47		0.29–0.75		0.002
Patients´ age	≥55 vs. < 55 years	OS	0.92		0.49–1.70		0.783
		PFS	0.84		0.46–1.54		0.571
Phenotype	T-ALL vs. B-ALL Ph neg	OS	0.85		0.53–1.37		0.505
		PFS	0.87		0.54–1.38		0.544
	B-ALL Ph pos vs. B-ALL Ph neg	OS	0.75		0.48–1.18		0.213
		PFS	0.71		0.46–1.10		0.128
Timepoint of allo-SCT	1995–2000 vs. 2011–2018	OS	2.28		1.24–4.18		0.008
		PFS	1.89		1.05–3.39		0.033
	2001–2010 vs. 2011–2018	OS	1.62		0.90–2.93		0.111
		PFS	1.50		0.85–2.66		0.163
(B) RR and NRM
Remission at allo-SCT	No remission vs. CR MRD nega	RR	4.02		2.38–6.80		<0.0001
		NRM	0.95		0.47–1.91		0.881
	CR MRD pos vs. CR MRD nega	RR	1.66		0.82–3.32		0.157
		NRM	0.76		0.36–1.63		0.486
Conditioning	TBI vs. no TBI	RR	0.68		0.36–1.27		0.225
		NRM	0.61		0.29–1.28		0.193
Patients´ age	≥55 vs. < 55 years	RR	0.58		0.24–1.43		0.238
		NRM	1.42		0.59–3.42		0.431
Phenotype	T-ALL vs. B-ALL Ph neg	RR	1.42		0.82–2.46		0.206
		NRM	0.48		0.20–1.18		0.112
	B-ALL Ph pos vs. B-ALL Ph neg	RR	0.55		0.30–1.03		0.061
		NRM	1.32		0.71–2.43		0.377
Timepoint of allo-SCT	1995–2000 vs. 2011–2018	RR	1.41		0.63–3.15		0.400
		NRM	2.56		0.95–6.92		0.063
	2001–2010 vs. 2011–2018	RR	1.91		0.87–4.22		0.108
		NRM	1.40		0.56–3.48		0.468

HR Hazard ratio, CI confidence interval, OS overall survival, PFS progression free survival, CR complete remission, MRD minimal residual disease, neg negative, pos positive, TBI total body irradiation, Ph Philadelphia chromosome, allo-SCT allogeneic stem cell transplantation, RR cumulative incidence of relapse, NRM cumulative incidence of non-relapse mortality.

^aAnalysis of Ig-/TR-gene rearrangements via RQ-PCR or surface marker analysis by flow cytometry.