Fig. 4.

Overview of whole-brain computational modeling to integrate multimodal and multiscale data. a Whole-brain models combine a model of local regional activity with information about connectivity between regions. Additional information can be provided about neuroanatomy (from structural magnetic resonance imaging [MRI]), brain function (from functional MRI), and neurobiology (e.g., receptor density distribution obtained from in vivo positron-emission tomography [PET]). b Models can be systematically perturbed at different spatial and temporal scales, intervening at the level of individual regions or their connections