Table 1.
Patient characteristics of both groups
| Characteristics | Control n = 23 |
Metformin n = 23 |
P value |
|---|---|---|---|
| Sex (female) | 7 | 5 | 0.738 |
| Age (years) | 65.2 ± 2.0 | 64.1 ± 1.8 | 0.604 |
| History of stroke (%) | 21.7 | 0 | 0.049* |
| History of MI (%) | 21.7 | 8.6 | 0.362 |
| CAD (%) | 43.4 | 39.1 | > 0.999 |
| Hypertension (%) | 100.0 | 100.0 | > 0.999 |
| PAD (%) | 30.4 | 21.7 | 0.738 |
| BMI (kg/m2) | 31.0 ± 1.1 | 33.6 ± 1.8 | 0.362 |
| Smoking (%) | 8.7 | 8.7 | > 0.999 |
| Neutrophils (%) | 61.4 (55–67) | 57.3 (46–64) | 0.089 |
| LDL cholesterol (mg/dL) | 114.6 ± 7.9 | 110.9 ± 8.7 | 0.402 |
| HDL cholesterol (mg/dL) | 42.1 ± 2.2 | 43.3 ± 3.2 | 0.948 |
| Total cholesterol (mg/dL) | 182.3 ± 9.1 | 203.0 ± 11.3 | 0.162 |
| Fibrinogen (mg/dL) | 399.0 ± 27.2 | 345.4 ± 18.9 | 0.228 |
| Myeloperoxidase (ng/mL) | 16.4 ± 2.6 | 8.8 ± 0.9 | 0.093 |
| CRP (mg/dl) | 0.4 (0.15–1.2) | 0.4 (0.23–0.63) | 0.883 |
| GFR (mL/min) | 56.0 (45–80) | 66.0 (58–87) | 0.339 |
| HbA1c (%) | 8.3 ± 0.3 | 8.4 ± 0.3 | 0.866 |
| HbA1c (mmol/mol) | 67.7 ± 3.5 | 68.5 ± 3.8 | 0.900 |
| Fasting blood glucose (mg/dl) | 154.3 ± 12.7 | 146.2 ± 9.1 | 0.806 |
| Medication | |||
| insulin (%) | 82.6 | 60.8 | 0.189 |
| Sulfonylurea (%) | 13.0 | 17.3 | > 0.999 |
| Acarbose (%) | 13.0 | 8.6 | > 0.999 |
| Glinides (%) | 4.3 | 13.0 | 0.607 |
n = 46; values presented are means ± SEM, medians (interquartile range) or percentages
BMI body mass index, CAD coronary artery disease, CRP c-reactive protein, GFR glomerular filtration rate, HbA1c glycated hemoglobin, HDL high-density lipoprotein, LDL low-density lipoprotein, MI myocardial infarction, PAD peripheral artery disease
* p < 0.05