Table A2:
Adjusted hazards ratio (95% CI) of recurrent stroke and death according to global and domain specific cognitive impairment across sensitivity analyses
| Outcomes | Censoring all participants after 5 years of follow-up* | Excluding participants with a history of stroke* | Adding time from qualifying stroke to baseline exam to follow-up* | |||
|---|---|---|---|---|---|---|
| Cognitive Domain | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value |
| Recurrent Stroke | ||||||
| Global Impairment (CASI ≤86) | 1.40 (0.95, 2.06) | 0.09 | 1.28 (0.85, 1.92) | 0.24 | 1.24 (0.86, 1.79) | 0.24 |
| CLOX Impairment (<10) | 1.08 (0.72, 1.63) | 0.7 | 1.10 (0.72, 1.67) | 0.67 | 0.93 (0.62, 1.38) | 0.71 |
| Memory Impairment (<Q1) | 1.59 (1.11, 2.30) | 0.01 | 1.57 (1.07, 2.31) | 0.02 | 1.47 (1.04, 2.08) | 0.03 |
| Non-Memory Impairment (<Q1) | 1.48 (1.01, 2.17) | 0.05 | 1.26 (0.84, 1.89) | 0.26 | 1.32 (0.92, 1.90) | 0.13 |
| All-Cause Mortality | ||||||
| Global Impairment (CASI <86) | 1.51 (0.90, 2.51) | 0.12 | 1.69 (1.03, 2.75) | 0.04 | 1.69 (1.08, 2.64) | 0.02 |
| CLOX Impairment (<10) | 0.92 (0.54, 1.55) | 0.75 | 1.00 (0.61, 1.62) | 0.98 | 0.91 (0.58, 1.44) | 0.69 |
| Memory Impairment (<Q1) | 1.54 (0.97, 2.45) | 0.07 | 1.90 (1.23, 2.94) | 0.004 | 1.89 (1.27, 2.82) | 0.002 |
| Non-Memory Impairment (<Q1) | 2.04 (1.26, 3.30) | 0.004 | 1.70 (1.08, 2.68) | 0.02 | 1.76 (1.15, 2.69) | 0.01 |
Abbreviations: CASI, Cognitive Assessment Screening Instrument; CLOX, Clock Drawing to Command; Q1, First quartile (<25th percentile) on sample z score.
All models are adjusted for Model 4 covariates: age, sex, race/ethnicity, education, blood pressure control group, dual antiplatelet treatment, stroke history, family stroke history, hypertension, hyperlipidemia, diabetes mellitus, cardiovascular disease history, smoking status, weekly alcohol use, days of exercise weekly, lacunar stroke location, modified Rankin score, Barthel activities of daily living, and age-related white matter changes scale score.