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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Nature. 2021 Jun 2;595(7866):295–302. doi: 10.1038/s41586-021-03609-w

Extended Data Figure 5. Off-target indel formation associated with ABE8e-NRCH conversion of HBBS to HBBG Makassar in sickle cell disease patient CD34+ hematopoietic stem and progenitor cells.

Extended Data Figure 5.

Bar graph showing the percentage of sequencing reads containing alleles harboring indels at on-and off-target sites in genomic DNA samples from patient CD34+ HSPCs treated with ABE8e-NRCH mRNA, protein, or untreated controls (n=4). Bar values and error bars reflect mean±SD.