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. 2021 May 10;16(4):517–527. doi: 10.1007/s11523-021-00816-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Kaplan–Meier progression-free survival and overall survival in patients overexpressing p53 (dotted line) and in patients non-overexpressing p53 (continuous line) in the validation cohort. a Median progression-free survival was 8.1 months (95% confidence interval [CI] 6.5–12.0) in patients non-overexpressing p53 vs 5.8 months (95% CI 3.0–11.4) in patients overexpressing p53 (hazard ratio: 0.48; p = 0.0399). b Median overall survival was 18 months (95% CI 13.6–28.0) in patients non-overexpressing p53 vs 11.4 months (95% CI 8.2–18.0) in patients overexpressing p53 (hazard ratio: 0.26; p = 0.0027)