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. 2021 May 10;16(4):517–527. doi: 10.1007/s11523-021-00816-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 5 — Kaplan–Meier overall survival from first-line palliative therapy in patients overexpressing p53 (dotted line) and in patients non-overexpressing p53 (continuous line) in the explorative (a) and the validation cohort (b). a Median overall survival was 30.2 months (95% confidence interval [CI] 26.9–47.9) vs 17.1 (95% CI 13.8–44.9) in patients with low p53 expression and in patients overexpressing p53, respectively (hazard ratio: 0.28; p < 0.0001) in the exploratory cohort. b Median overall survival was 34.7 months (95% CI 25.8–40) vs 22.5 (95% CI 17–34) in patients with low p53 expression and in patients overexpressing p53, respectively (hazard ratio: 0.17; p = 0.0003) in the validation cohort