Table 2.

Effect of bempedoic acid on select laboratory values of interest (overall pool) [40]

Parameter	Exposure-adjusted incidence per 100 person-years (n)
	ASCVD/HeFH on statins pool		Statin intolerant pool
	Bempedoic acid (n = 2009)	Placebo (n = 999)	Bempedoic acid (n = 415)	Placebo (n = 198)
ALT and/or AST > 3 × ULNa	0.6 (13)	0.3 (3)	2.8 (5)	0
ALT and/or AST > 5 × ULNa	0.2 (4)	0.2 (2)	1.1 (2)	0
Blood creatinine levels increased	0.9 (16)	0.4 (4)	1.8 (3)	0
Blood urea levels increased	0.2 (3)	0.1 (1)	0	0
Blood uric acid levels increased	1.8 (33)	0.4 (4)	10.7 (18)	2.4 (2)
Creatine kinase >5 × ULNa	0.3 (7)	0.2 (2)	0.6 (1)	0

ALT alanine aminotransferase, AST aspartate aminotransferase, ULN upper limit of normal

^aPatients with repeated and confirmed elevations in aminotransferase or creatine kinase levels