Table 1.
Hematology and serum metabolic profiles of Il11 knockout mice.
| Blood counts | Il11+/+ (n = 5) | Il11−/− (n = 7) | Sig.a |
|---|---|---|---|
| WBC (109/L) | 6.74 ± 2.60 | 6.30 ± 1.60 | NS |
| Lymphocytes (109/L) | 5.00 ± 1.83 | 4.84 ± 1.67 | NS |
| Monocytes (109/L) | 0.23 ± 0.16 | 0.31 ± 0.31 | NS |
| Neutrophils (109/L) | 1.52 ± 1.65 | 1.15 ± 0.98 | NS |
| RBC (1012/L) | 10.18 ± 2.46 | 9.02 ± 0.21 | NS |
| HGB (g/dL) | 11.98 ± 2.23 | 13.52 ± 0.43 | NS |
| HCT (%) | 45.42 ± 12.16 | 40.66 ± 1.16 | NS |
| Platelets (109/L) | 521 ± 358 | 387 ± 75 | NS |
| Mean Platelet Volume (fl) | 6.12 ± 0.16 | 6.15 ± 0.26 | NS |
| Serum metabolic markers | Il11+/+ (n = 5) | Il11−/− (n = 6) | Sig.a |
|---|---|---|---|
| Albumin (g/dL) | 3.34 ± 0.32 | 3.23 ± 0.30 | NS |
| Alkaline Phosphatase (U/L) | 89.20 ± 7.33 | 98.83 ± 21.15 | NS |
| Alanine Aminotransferase (U/L) | 35.00 ± 20.10 | 59.17 ± 27.69 | NS |
| Amylase (U/L) | 730 ± 142 | 696 ± 91 | NS |
| Total Bilirubin (mg/dL) | 0.32 ± 0.04 | 0.32 ± 0.04 | NS |
| Blood Urea Nitrogen (mg/dL) | 20.00 ± 5.39 | 19.67 ± 3.56 | NS |
| Calcium (mg/dL) | 9.62 ± 0.16 | 9.67 ± 0.55 | NS |
| Phosphate (mg/dL) | 10.88 ± 2.20 | 10.57 ± 0.96 | NS |
| Glucose (mg/dL) | 328 ± 108 | 389 ± 91.91 | NS |
| Sodium (mmol/L) | 147 ± 1.87 | 143 ± 3.92 | NS |
| Potassium (mmol/L) | 5.24 ± 0.44 | 5.43 ± 0.67 | NS |
| Total Protein (g/dL) | 4.34 ± 0.17 | 4.10 ± 0.13 | NS |
| Globulin (g/dL) | 0.98 ± 0.19 | 0.83 ± 0.23 | NS |
Data shown as mean ± SD.
WBC white blood cells, RBC red blood cells, HGB hemoglobin count, HCT hematocrit, NS non-significant.
aSignificance was determined using Bonferroni post-hoc test.