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. 2021 Jul 8;7:57. doi: 10.1038/s41531-021-00199-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–c R2* changes in Parkinson’s disease. Main effect of disease on brain iron, as assessed by R2*, displayed at p < 0.001 uncorrected over the mean structural image of the whole population. Color scales are proportional to t values. d–f Relationship between R2* and NM-sensitive MRI data. f Peak voxel ESNV skewness in both SN increases as R2* increases in left SN, significantly more in PD patients than HC. g–i Relationship between dopaminergic neurotransmission ([18F]DOPA PET) and NM-sensitive MRI data. Regression between peak voxel in left anterior putamen Ki and bilateral SN ESNV skewness. j–l Relationship between dopaminergic neurotransmission ([18F]DOPA PET) and R2*. Peak voxel Ki values in posterior putamen regressed differentially in PD and HC with lateral SN R2*. All results are displayed at p < 0.001 uncorrected over the mean structural image of the whole population. Color scales are proportional to t values.