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. 2021 Jul 8;7:176. doi: 10.1038/s41420-021-00524-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The heatmap of miRNA array assay. B The top ten up-regulated and down-regulated miRNAs were listed. C, D The top ten up-regulated or down-regulated exosomal miRNAs verification in CAFs sEVs. miRNA levels were evaluated by real-time RT-PCR. E MiR-7641 expression in five paired sEVs from CAFs and NFs of breast cancer tissues. F MiR-7641 expression in breast cancer tissues and their adjacent tissues (n = 79). N: adjacent normal tissues; T: breast cancer tissues. G MiR-7641 expression in breast cancer tissues and their adjacent tissues using FISH assay. N: adjacent normal tissues; T: breast cancer tissues. H The expression of miR-7641 in breast cancer cells with different subtypes and normal breast epithelial cells (MCF10A). *p < 0.05, **p < 0.01.