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. 2021 Jul 8;11:14099. doi: 10.1038/s41598-021-93421-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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24-h MIC fluconazole of 117 (2011–2012), and 106 (2017–2018) strains of C. albicans. (A) Illustrate chart bar (left) which each bar is labeled with the number of isolates and logarithmic scales (right) of 24-h MIC fluconazole during p2 (2017–2018) which Frequency of MIC results is presented in error bars with 95% CI. Each error bar is labeled by circles that are representative of MIC frequency. (B) Illustrate chart bar (left) and logarithmic scales (right) of 24-h MIC fluconazole during p1 (2011–2012). MIC distribution histogram also is provided for better comparison between the two periods.