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. 2021 Jul 8;4:849. doi: 10.1038/s42003-021-02360-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Pseudo-periodic pattern of repeating lumps (blue arrows) along the length of an mEx1-Q51 filament as seen in an xy slice (4.4 Å thick) from a tomogram of aggregated mEx1-Q51. b Selected regions from semi-automated neural network annotations showing lumpy filaments of various widths, including sheet-like regions (middle region of right-most example). c Subtomogram average of a subpopulation of filament segments (n = 450) exhibiting a lumpy ~7 × 15 nm slab-shaped morphology. Scale bars: 50 nm (a, b), 15 nm and 7 nm (c).