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. 2021 Jun 25;8:660269. doi: 10.3389/fmolb.2021.660269

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Copyright © 2021 Xu, Ma and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depletion of circTLK1 decreases oxidation stress, inflammation, and apoptosis in the sepsis-related AKI rat model. (A–G) The CLP-induced sepsis-related AKI rat model was established in Wistar rats (N = 4), followed by the treatment of circTLK1 shRNA. The cecum was exposed without perforation in the sham groups. (A) MDA levels in the rats. (B) ROS production in the rats. (C) GSH levels in the rats. (D) CAT activities in the rats. (E) SOD activities in the rats. (F) IL-1β and IL-6 release in the rats. (G) TUNEL assays of apoptosis analysis in the rats, bar = 50 μm. The experiments were replicated at least three times, mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001.