TABLE 4.

Immune signatures of cervical cancer related to prognosis

	Favorable prognosis	Unfavorable prognosis
Hematological Markers	↑ ALC 20 , 21 , 22 ↑ relative lymphocyte count 27 ↑ ELR 44 ↑LMR 21	↑ ANC 34 , 35 , 36 ↑ relative rate of on treatment ALC decline 32 ↑ NLR 27 , 37 , 39 , 40 , 41 , 42 ↑ AMC 61
Other Immune Markers	↑CD8+ T cells in the tumor microenvironment 56 , 57 ↑ FoxP3 in the tumor microenvironment 56 HPV E1‐specific T‐cell response 45 ↑ tumor‐associated neutrophils (CD66+) 64 M1>M2 TAMs 61 Th1>Th2 cytokine balance 51 , 84 ↓TGF‐β1 52 ↓ VEGF 52	↓ CD8+ T cells 60 ↓ PRF1, GAMA, GNLY expression by T cells 60 ↑ lymphocyte radiosensitivity 46

Abbreviations: ALC, absolute lymphocyte count; AMC, absolute monocyte count; ANC, absolute neutrophil count; ELR, eosinophil‐to‐lymphocyte ratio; FoxP3+, Forkhead box P3; GAMA, granzyme A; GNLY, granulysin; HPV, human papillomavirus; LMR, lymphocyte‐to‐monocyte ratio; NLR, neutrophil‐to‐lymphocyte ratio; PDL, programed cell death ligand; PRF1, perforin; TGF‐, tumor growth factor‐; Th, T‐helper cell; VEGF, vascular endothelial growth factor.