TABLE 3.
Univariate and multivariate Cox analyses in the training set
| Variable | Category | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95%CI) | p value | HR (95%CI) | p value | ||
| Age | Continuous | 1.03 (1.00–1.04) | 0.027 | 1.03 (1.01–1.05) | 0.006 |
| Gender | Female vs. Male | 0.89 (0.54–1.44) | 0.625 | – | – |
| Tumor site | Oral cavity vs. Larynx | 1.13 (0.67–1.90) | 0.660 | – | – |
| Oral cavity vs. Pharynx | 1.19 (0.56–2.55) | 0.649 | – | – | |
| TNM stage | Ⅰ vs. Ⅱ | 2.12 (0.75–6.01) | 0.158 | 2.05 (0.72–5.82) | 0.178 |
| Ⅰ vs. Ⅲ | 2.39 (0.85–6.75) | 0.099 | 2.30 (0.82–6.59) | 0.116 | |
| Ⅰ vs. Ⅳ | 3.60 (1.33–9.72) | 0.011 | 2.38 (1.15–5.13) | 0.026 | |
| Tumor grade | G1 vs. G2 | 1.79 (0.93–3.44) | 0.082 | 2.23 (0.99–5.00) | 0.052 |
| G1 vs. G3 | 1.34 (0.65–2.77) | 0.434 | 1.69 (0.71–4.06) | 0.239 | |
| Transcriptional subtype | Classical vs. Atypical | 0.55 (0.29–1.02) | 0.058 | 1.05 (0.54–2.01) | 0.896 |
| Classical vs. Basal | 0.61 (0.34–1.08) | 0.087 | 1.07 (0.58–1.98) | 0.832 | |
| Classical vs. Mesenchymal | 0.67 (0.38–1.18) | 0.162 | 1.30 (0.72–2.36) | 0.391 | |
| HTRS | Low‐risk vs. High‐risk | 4.09 (2.34–7.15) | <0.001 | 5.17 (2.82–9.41) | <0.001 |
Abbreviations: CI, confidence interval; HR, hazard ratio; HTRS, histopathological transcriptomics risk score.