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Effect of CRS on depressive-like behaviors in MMTV-PyVT mice. CRS robustly induced notable depressive-like behaviors in MMTV-PyMT mice, which was be relieved by the antidepressant Xiaoyao pill. (A) Schematic timeline of the experimental procedures. Antidepressant-like effects of antidepressant Xiaoyao pill on MMTV-PyMT mice in open-field (B) and light/dark box (C) tests. **, P<0.01; ***, P<0.001. CRS, chronic restraint stress; SEM, standard error of mean; XYP, Xiaoyao pill.
