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. 2021 Jun;9(12):1017. doi: 10.21037/atm-21-2767

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Cancer-associated fibroblasts (CAFs) subclusters are associated with poor survival in head and neck squamous cell carcinoma (HNSCC) patients. (A) Most CAFs subclusters (except from cluster 7) showed significantly higher expression in tumor tissues from TCGA database; (B) Kaplan-Meier curve showing the impact of the relative presence of these CAFs subclusters on HNSCC patients’ overall survival. Patients with a relatively higher expression of CAFs clusters 0, 3, and 4 had a poorer overall survival (P<0.05).