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. 2021 Mar 25;12(2):689–713. doi: 10.1016/j.jcmgh.2021.03.008

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Distinctive copy number alterations across individual chromosomes in CP-B cells following SMAD4 knockdown/knockout and tumorigenic transformation in vivo. Copy number changes for individual chromosomes 6, 8, 12, 14, and 20 in SMAD4 wild-type cells (CP-B Parental; CP-B Cas9; CP-B pGIPZ); SMAD4 knockout (CP-B Ex1) and SMAD4 knockdown (CP-B sh1) cells grown in vitro only; tumorigenic SMAD4 knockdown (CP-B S1-1, S1-2, S1-3, S1-4) and knockout (CP-B E1-1, E1-2, E1-3) cells derived from xenograft tumors (see Table 1 for more details). Plots were constructed via Control-FREEC tool. Red and blue colors represent gains and losses, respectively, whereas green colour represents no changes in copy number. Scale of the x axis is presented in megabase pairs (Mb).