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. 2021 Mar 25;12(2):689–713. doi: 10.1016/j.jcmgh.2021.03.008

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Histological characterisation of SMAD4 knockdown or knockout xenograft tumors. Representative H&E (upper panels) and human specific mitochondrial staining (lower panels) of (A, B) SMAD4 knockdown tumor xenografts (CP-B S2-2; CP-B S2-1); and (C, D) SMAD4 knockout tumor xenografts (CP-B E1-1; CP-B E1-3). Red arrows point to cells with spindle like morphology. Representative CK7 immunohistochemistry staining across SMAD4 knockdown (E) CP-B S2-1; (F) CP-B S1-1; and SMAD4 knockout (G) CP-B E1-2 tumor xenografts. Scale bars represent 100 µm.