Table 2.

Summary of Frequent CNAs (LC-WGS) Across Cell Lines Rederived From SMAD4 Knockdown and Knockout Xenograft Tumors

Chromosome	SMAD4 knockdown (in vitro)	SMAD4 knockout (in vitro)	Tumorigenic SMAD4 knockdown				Tumorigenic SMAD4 knockout
	Sh1	Ex1 clone	S1-1	S1-2	S1-3	S1-4a	E1-1a	E1-2a	E1-3
6		6bq22.31-23.3b	6p12.1-11.2c	6p12.1-11.2c			6q22.31-23.3b, 6q22.1c	6q22.31-23.3b, 6q22.1c, 6p12.1-11.2c	6q22.31-23.3b, 6q22.1c
7							7q11.22-11.23c, 7q11.23-36.3b	7q11.23-36.3 partialb	7q11.22-11.23c, 7q11.23-36.3b
8		8qc	8qc	8qc	8q partialc	8qc	8qc	8qc	8qc
12			12p12.2-11.21 partialc, 12qc	12p13.33-11.21 partialc, 12qc			12p13.33-11.21 partialc, 12qc	12p13.33-11.21 partialc, 12qc	12p13.33-11.21c
14						14q21.1-24.3b	14q21.1-24.3	14q21.1-24.3b	14q21.1-24.3b
17		17pc	17pc	17pc	17pc	17pc	17pc	17pc	17pc
20							20pc		20pc

^aMetastatic cell lines.

^bCopy number loss.

^cCopy number gain.