Fig. 4.

Ultrastructural changes in hamster livers were revealed by transmission electron microscopy (TEM). Hamsters were evaluated in the control group and 24 h after oral administration of blank nanocomplexes (BNCs) or a high dose of curcumin-loaded nanocomplexes (CNCs) (1.61 g/kg bw, equivalent to 0.45 g/kg bw of curcumin). The TEM images were obtained at 100 kV and recorded using JEM-1010 TEM, (JEOL, Japan). The scale bar is 800 nm. The original magnification for liver tissues of hamsters was x 20,000. Representative data are shown (n = 2 animals/group) in the normal, BNCs-treated and CNCs high-dose groups. Abbreviations are for mitochondria (m) and endoplasmic reticulum (ER).