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. 2021 Jun 25;12:651083. doi: 10.3389/fpsyt.2021.651083

Table 4.

Relationship between IL-8 and GM-CSF and the widespreadedness of pain in the patient group.

No. of sites with pain B (CI) P
IL-8
(Intercept) −1.14 (−2.19 to 0.08) 0.036
Sex 1.06 (0.5 to 1.6) <0.001
Age 0 (−0.01 to 0) 0.399
BMI 0.01 (−0.0to 0.03) 0.177
Anxiety 0.02 (0.02 to 0.05) 0.432
Depression 0 (−0.03 to 0.04) 0.890
Fatigue 0.06 (0.03 to 0.08) <0.001
Stress 0 (−0.02 to 0.03) 0.909
Pain intensity 0.03 (−0.3 to 0.09) 0.355
IL-8 1.44 (0.09 to 2.78) 0.036
Sex * IL-8 −1.30 (−2.14 to 0.45) 0.003
GM-CSF
(Intercept) 0.31 (−0.58 to 1.20) 0.493
Sex 0.34 (0.12 to 0.57) 0.004
Age 0 (−0.01 to 0) 0.283
BMI 0.01 (−0.01 to 0.03) 0.274
Anxiety 0 (−0.04 to 0.04) 0.961
Depression 0.01 (−0.03 to 0.05) 0.586
Fatigue 0.05 (0.02 to 0.08) <0.001
Stress 0.01 (−0.01 to 0.04) 0.610
Pain intensity 0.02 (−0.04 to 0.08) 0.460
GM-CSF −0.36 (−0.70 to 0.02) 0.039

Means, 95% confidence intervals and p-values for the models including IL-8 and GM-CSF presented. The estimates represent the change in relation to log-transformed values of the cytokine analysis.