TABLE 3.

Cluster of HCC-CIR PPI Network.

Cluster	Score	Nodes	Edges	Genes and targets
1	35.244	46	793	MAPK14, SOD2, MAPK8, MDM2, SRC, MET, PLG, EGFR, TP53, CASP3, CAT, HMOX1, MMP2, ESR1, MMP3, HSPB1, CCNA2, HPGDS, FOS, TLR4, MAPK3, HRAS, JUN, AKT1, AKT2, CDC42, PTK2, ALB, HSP90AA1, PTPN11, CYCS, NOS3, IGF1, IGF1R, IL2, RAF1, EDN1, JAK2, RHOA, NGF, TLR2, VEGFA, GRB2, PGR, MAP2K1, MAPK1
2	11	47	253	MAPK10, ABL1, ACE, PLAU, THBS1, STAT1, EIF4E, MMP1, CASP1, MMP13, CASP7, PPARG, ERBB4, ESR2, CCL5, MMP7, MMP9, CDK2, PTK2B, PTPN1, NOS2, HSPA8, NQO1, CHEK1, RAC1, FGFR2, ANXA5, APAF1, NR3C1, AR, XIAP, CRYZ, CSK, JAK3, REN, EGR1, KDR, SOD1, KIT, PARP1, LCK, PIK3CA, BCL2L1, SELE, BMP2, GSK3B, GSR
3	7.932	60	234	BRAF, SLC2A1, GSTA1, BTK, NOS1, GSTP1, ANGPT1, CALM1, HCK, HEXB, PRKCQ, FAS, CDK6, HSP90AB1, HSPA1A, C3, RAC2, IMPDH1, INSR, RARA, DIABLO, PARK7, RHEB, CTSB, RNASE2, RNASE3, CTSG, LGALS3, LYZ, SELP, ADAM17, ELANE, EPHA2, SYK, TEK, AKR1B1, TGFBR1, F2, FABP5, TTR, FGF1, FGFR1, VDR, G6PD, ARG1, ZAP70, ARSA, BAX, ATIC, NTRK1, AURKA, NFE2L2, GLRX, GM2A, PDPK1, KEAP1, PGF, PIK3CG, BPI, PIK3R1
4	7.714	15	54	TKT, TYMP, IMPDH2, UCK2, DTYMK, UMPS, APRT, PNP, APEX1, GART, ADK, GLO1, GMPR, TK1, DCK
5	5.579	20	53	SIRT5, CHIT1, SPARC, DUT, CANT1, BCL2, HK1, PPIA, CTSD, AIFM1, HPRT1, TGM2, CTSS, CDA, LTA4H, LTF, SIRT3, ALDOA, UCP2, QPCT
6	4.4	6	11	CYP2C8, GSTA3, CYP2C9, ADH1B, GSTO1, ADH1C
7	3.846	14	25	TYMS, PKLR, SORD, NT5M, CALM2, YARS, PPP1CC, LDHB, MTHFD1, PDE5A, GMPR2, GPI, PYGL, SHMT1
8	3.333	4	5	PSEN1, GRIA1, BACE1, DLG4
9	3.176	18	27	FECH, DHFR, GRIK2, DHODH, C1R, C1S, C5, FGG, PAH, AHCY, GLUL, SLC1A3, ALAD, BHMT, GRIK1, SERPINA1, TPI1, GRIA4
10	3	3	3	GSTM2, GSS, GSTM1
11	3	3	3	EEA1, RAB11A, RAB5A
12	3	3	3	UAP1, GNPDA1, GNPDA2
13	2.909	12	16	GC, GRIN2B, TGFB2, TGFBR2, FKBP1A, APOA2, RBP4, CALM3, DAPK1, TF, BMP7, CFD
14	2.875	17	23	MBL2, APCS, RARB, RARG, STS, OTC, ARG2, SULT2A1, GATM, F11, RXRA, AKR1C3, F7, THRB, PSPH, CDK7, CFB